WebCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes … WebMar 21, 2024 · UGT2B10 (UDP Glucuronosyltransferase Family 2 Member B10) is a Protein Coding gene. Diseases associated with UGT2B10 include Crigler-Najjar Syndrome, …
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WebNov 25, 2016 · Because the previous results indicate that ethanol-induced Cyp2b10 expression was not mediated by CAR activation, functional mapping of the 5′ upstream region of the Cyp2b10 gene was performed to identify important regulators that may influence ethanol-induced Cyp2b10 expression. Reporter gene assays revealed that the … WebMar 5, 1999 · A PB-responsive enhancer activity was first associated with a 177-bp DNA sequence (−2318/−2155 bp) of the rat CYP2B2 gene in primary hepatocytes (3) and was …
WebCyp2b10 Name cytochrome P450, family 2, subfamily b, polypeptide 10 Synonyms Cyp2b, Cyp2b20, p16, phenobarbitol inducible, type b Feature Type protein coding gene IDs … WebFeb 17, 2003 · The CYP2B10 mRNA is expressed in the lungs of both wild-type and CAR-null mice, and is not induced by PB treatment (Fig. 3). Thus, CAR does not regulate the constitutive expression of the Cyp2b10 gene in mouse lung. Whether CAR regulates the Cyp2b10 expression in mouse intestine remains to be investigated. Download : …
WebA distal gene fragment, at about -2000 kb in CYP2B1, CYP2B2, and Cyp2b10, has been shown to be a phenobarbital-responsive enhancer independent of proximal promoter … WebApr 13, 2024 · From QR codes to credit card swipers, restaurants are now managing more tech than ever ... Gene Marks CPA Business Keynote Speaker, Author, Columnist, Business Owner Published Apr 13, 2024 ...
WebMar 27, 2024 · GeneCards is a searchable, integrative database that provides comprehensive, user-friendly information on all annotated and predicted human genes. The knowledgebase automatically integrates gene-centric data from ~150 web sources, including genomic, transcriptomic, proteomic, genetic, clinical and functional information. …
WebOct 29, 2024 · Nitrapyrin-induced liver weights and Cyp2b10 gene expression for both males and females were compared to data generated from three other established CAR activators; methyl isobutyl ketone, phenobarbital, and sulfoxaflor. The response observed in female mice following exposure to nitrapyrin was within range of the degree of change … top shoes in bryant arWebThe nuclear receptor constitutive active/androstane receptor (CAR) is sequestered in the cytoplasm of liver cells before its activation by therapeutic drugs and xenobiotics such as phenobarbital (PB) and 1,4-Bis [2- (3,5-dichloropyridyloxy)]benzene (TCPOBOP) in mouse liver, the regulatory mechanism of which remains poorly understood. top shoes in ashevilleWebCyp2b10cytochrome P450, family 2, subfamily b, polypeptide 10 [ Mus musculus(house mouse) ] Gene ID: 13088, updated on 26-Sep-2024 Download Datasets Gene … top shoes in 2022WebNov 1, 2000 · Abstract. The nuclear orphan receptor CAR (constitutively active receptor or constitutive androstane receptor) can be activated in response to xenochemical exposure, such as activation by phenobarbital of a response element called NR1 found in the CYP2B gene. Here various steroids were screened for potential endogenous chemicals that may … top shoes in bentonWebOn the other hand, progesterone and androgens repressed NR1 activity in HepG2 cells, and the repressed NR1 activity was fully restored by estradiol. Moreover, estrogen treatment elicited nuclear accumulation of CAR in the mouse livers, as well as primary hepatocytes, and induced the endogenous Cyp2b10 gene. top shoes macapáWebEthanol-induced Hepatic Cyp2b10 Expression Is Regulated by PPAR / -dependent Modulation of SP1 Activity—Because the previous results indicate that ethanol-induced Cyp2b10 expression was not mediated by CAR activation, functional mapping of the 5 upstream region of the Cyp2b10 gene was performed to identify important regulators … top shoes menWebNov 23, 2024 · Expression of CYP2B10 is known to be regulated by a number of nuclear receptors such as pregnane X receptor (PXR), constitutive androstane receptor (CAR), glucocorticoid receptors (GR), and vitamin D receptor (VDR) ( Beigneux et al., 2002; Pascussi et al., 2004 ). Period 2 (PER2) is a central component of the mammalian … top shoes in india